The effect of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons.
نویسندگان
چکیده
Hepatic cholesterol synthesis. hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt. Cholesterol synthesis as measured with acetate incorporation was reduced in both species, Hepatic cyclic AMP increased in dogs, Changes in portal and systemic insulin were inconsistent. but hyperglucagonemia occurred regularly, Diminished hepatic cholesterol synthesis is apparently one factor, although probably not the only one, in the antilipidemic effect of portacaval shunt. This altered cholesterol metabolism may be due to a change in the hormonal environment of the liver caused by portal diversion,
منابع مشابه
The influence of portal blood upon lipid metabolism in normal and diabetic dogs and baboons.
Complete diversion of portal blood in dogs caused sustained falls in serum cholesterol and phospholipid concentrations an declines in hepatic cholesterol and triglyceride synthesis. The hepatocytes in these canine livers were deglycogenated, and they atrophied to about half of their original size within two months. At the same time, there was evidence of increased mitoses. Ultrastructurally, th...
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عنوان ژورنال:
- The Journal of surgical research
دوره 28 1 شماره
صفحات -
تاریخ انتشار 1980